MPRI is housed in the Biosciences Research Building at the University of Maryland, College Park. The building houses the research programs of about 35 faculty investigators. The entire top floor, which includes two $2.4 million BSL-3 facilities, is dedicated to pathogen research. The floor below is devoted to research in functional genomics – a field that is tightly linked with pathogen research.

The College of Chemical and Life Sciences has also created four new multi-user core facilities that house and maintain high-end, state-of-the-art instrumentation vital to the research activities of a broad spectrum of faculty investigators. These facilities include: Advanced Genomics Facility; Biological Imaging and Cell Sorting Facility; Proteomics and Mass Spectroscopy Facility; and CLFS Scientific Computing Facility.

The close proximity of the University of Maryland to governmental agencies, including the National Institutes of Health, Food and Drug Administration, the Biodefense Laboratories at Fort Dietrick and Fort Meade, as well as top research facilities such as Johns Hopkins University, University of Maryland Biotechnology Institute (UMBI), National Children's Medical Center, University of Maryland School of Medicine, and over 300 biotechnology companies will greatly add to the strength and success of MPRI. In addition, the institute has key synergistic ties on campus with the Sloan Center for Biotechnology and the new Department of Bioengineering.